Breakthrough on a Cure for AIDs

Still years from being available from doctors – but really promising research!

Advance in Quest for HIV Vaccine

HIV research is undergoing a renaissance that could lead to new ways to vaccinate against the AIDS virus and other viral diseases.

In the latest development, U.S. government scientists say they have discovered three powerful antibodies, the strongest of which neutralizes 91% of HIV strains, more than any AIDS antibody yet discovered. They are now deploying the technique used to find those antibodies to identify antibodies to influenza viruses.

The HIV antibodies were discovered in the cells of a 60-year-old African-American gay man, known in the scientific literature as Donor 45, whose body made the antibodies naturally. The trick for scientists now is to develop a vaccine or other methods to make anyone’s body produce them as well.

That effort “will require work,” said Gary Nabel, director of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases, who was a leader of the research. “We’re going to be at this for a while” before any benefit is seen in the clinic, he said.

The research was published Thursday in two papers in the online edition of the journal Science, 10 days before the opening of a large International AIDS Conference in Vienna, where prevention science is expected to take center stage. More than 33 million people were living with HIV at the end of 2008, and about 2.7 million contracted the virus that year, according to United Nations estimates.

Vaccines, which are believed to work by activating the body’s ability to produce antibodies, eliminated or curtailed smallpox, polio and other feared viral diseases, so they have been the holy grail of AIDS research.

Last year, following a trial in Thailand, results of the first HIV vaccine to show any efficacy were announced. But that vaccine reduced the chances of infection only by about 30%, and controversy erupted because in one common analysis the results weren’t statistically significant. That vaccine wasn’t designed to elicit the new antibodies.

The new discovery is part of what Wayne Koff, head of research and development at the nonprofit International AIDS Vaccine Initiative, calls a “renaissance” in HIV vaccine research.

Antibodies that are utterly ineffective, or that disable just one or two strains, are common. Until last year, only a handful of “broadly neutralizing antibodies,” those that efficiently disable a large swath of HIV strains, had been discovered. And none of them neutralized more than about 40% of known HIV variants.

But in the past year, thanks to efficient new detection methods, at least a half dozen broadly neutralizing antibodies, including the three latest ones, have been identified in peer-reviewed journals. Dennis Burton of the Scripps Institute in La Jolla, Calif., led a team that discovered two broadly neutralizing antibodies last year; he says his team has identified additional, unpublished ones. Most of the new antibodies are more potent, able to knock out HIV at far lower concentrations than their previously known counterparts.

Prison Rape, and the Spread of AIDs in Black Urban Communities

This should be a Civil Rights issue adopted by the so called “black leaders” who are remnants of the Civil Rights era. It shouldn’t take a rocket scientist to figure out the high rate of AIDs in the black urban community is related to the high rate of incarceration of black males. It is another component of genocide…

It’s Time to End the Epidemic of Prisoner Rape

When Bryson Martel was sentenced to six years in prison for check fraud, he was 28 years old, weighed 123 pounds, and was scared to death. He had good reason to be afraid. Within weeks of his arrival, he was beaten and raped at knifepoint. Martel reported the assault to staff, who moved him to “protective custody” – into a cell with a known rapist.

Days later, he was raped again.

Prison authorities should have taken particular care to protect Martel’s safety, knowing that he was a target for abuse. They didn’t, and the assaults continued. Over the course of nine months, Martel estimates he was raped by 27 different people. Ultimately, he was infected with HIV, and now has full-blown AIDS.

Alicia Keys Changing Lives In Africa (Helping Families Dealing With Aids & More)

Alicia Keys making a difference.

more about “Alicia Keys Changing Lives In Africa …“, posted with vodpod